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Filip Ottosson

Metabolomics in Cardiometabolic disease - A population-based perspective Background Type 2 diabetes (T2DM) and coronary artery disease (CAD) are major health concerns worldwide, that are preceded by metabolic alterations occuring years before clinical manifestation. These metabolic alterations could be characterized by shifts in plasma levels of metabolites, small molecules that partake in the che

https://www.ludc.lu.se/education-training/theses/theses-2019/filip-ottosson - 2025-07-03

Tania Singh Diwan

The Role of Maf Transcription Factors in Islet Inflammation and Beta Cell Function Endocrine disorders that lead to a state of chronic high blood glucose levels re collectively referred to as diabetes. This metabolic disease is mainly categorized into type 1 (T1D) and type 2 diabetes (T2D). These diabetic forms aricinate from distinct triggering environmental, genetic and altered mechanisms. T2D i

https://www.ludc.lu.se/education-training/theses/theses-2019/tania-singh - 2025-07-03

Prize winner 2018

Prize winner Olov Andersson, professor KI, Stockholm, Sweden Olov Andersson Olov Andersson´s research addresses one of the most important aspects of diabetes: how can we find new targets for effective and safe treatment of these diseases. One major approach Andersson has pursued is stimulation of the generation/regeneration of islet cells, thereby improving insulin secretion. Here, his work has be

https://www.ludc.lu.se/prize-winner-2018 - 2025-07-03

Experimental Cardiovascular Research Unit

Department of Clinical Sciences Malmö Head: Jan Nilsson, PI BackgroundCardiovascular disease (CVD) is a major cause of mortality among subjects with diabetes. The risk of myocardial infarction (MI) is increased 2-3 fold in subjects who have had diabetes for >10 years, with some studies reporting risks equivalent to that of a non-diabetic person with previous MI. Diabetes is also associated with an

https://www.ludc.lu.se/experimental-cardiovascular-research-unit - 2025-07-03

Cardiovascular Research - Cellular Metabolism and Inflammation

Focal accumulation of immune cells and lipids in the vascular wall leads to the formation of atherosclerotic plaques. Plaques occasionally erode or rupture, causing the blood to clot and restrict blood flow, with serious clinical consequences such as acute myocardial infarctions and strokes. Even though our understanding of the disease mechanisms underlying atherosclerosis has advanced substantial

https://www.ludc.lu.se/research-0/experimental-cardiovascular-research/cardiovascular-research-cellular-metabolism-and-inflammation - 2025-07-03

Kate Louise Möller Herum

Current positionGuest researcher, Biotech Research & Innovation Centre (BRIC), University of CopenhagenKate [dot] Herum [at] bric [dot] ku [dot] dkThesis titleSyndecan-4 in cardia fibroblasts - Role in regulation of extracellular matrix and myocardial stiffnessLists of papers included1) K.M. Herum, I.G. Lunde, B. Skrbic, G. Florholmen, D. Behmen, I. Sjaastad, C.R. Carlson, M.F. Gomez & G. Christen

https://www.ludc.lu.se/research-0/diabetic-complications/lab-alumni/kate-louise-moller-herum - 2025-07-03

Mitocondria

We shall explore genetic function by a combination of genetic and functional assays. First, via expression profiling, we intend to determine which genes for mitochondrial proteins are altered in pancreatic β-cells, liver, skeletal muscle, and adipose tissue. This will be performed in material from i) humans with or without the disease, ii) in genetically or pharmacologically manipulated animals an

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/mitocondria - 2025-07-03

Islets

To accomplish these goals we will: A) establish the stimulus-secretion coupling in human pancreatic islets from non-diabetic organ donors to obtain proof of concepts derived from rodent studies; these data will also establish the gold standard for efforts to differentiate embryonic stem cells into mature islet cells. B) Combine islet studies with genetic and metabolic studies in humanA) Our knowle

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/islets - 2025-07-03

Meetings, a prerequisite for change

How do we get people from different cultures, industries and worlds to sit down and talk to each other? First, they need to be brought together, and this alone requires the right person for the job. Meet Paola Hjelt, member of Lund University Diabetes Centre’s Innovation Board, who talks about on how to accomplish a change of mindset. She grew up in Brussels, Belgium, has one degree from the Stock

https://www.ludc.lu.se/meetings-prerequisite-change - 2025-07-03

The Metabolic Surgery Action Group

PI: Nils Wierup The emergence of morbidly obese patients has prompted novel approaches to achieve weight reduction. Given that energy reduction by dieting is largely unsuccessful in this paitent group, surgical procedures have instead been developed to dramatically restrict food intake. Indeed, over the course of months patients may loose up to 50% in body weight. In addition, the majority of pati

https://www.ludc.lu.se/about-us/action-groups/metabolic-surgery-action-group - 2025-07-03

The GPCR Action Group

PI: Albert Salehi The antiology of metabolic syndrome and type 2 diabetes is complex and involves the interaction between both genetic and environmental factors (also including nutritional and metabolic signals). It has been known for at long time that dysfunction fo pancreatic islets cell (α-, β- and δ-cell) is a critical factor in the development and progression of these diseases.One of the larg

https://www.ludc.lu.se/about-us/action-groups/gpcr-action-group - 2025-07-03